An Australian stem cell and regenerative medicine company

Diabetic wounds

What is a diabetic wound?

Due to reduced blood flow, patients with diabetes are at risk of developing non-healing or infected wounds. These wounds (also known as diabetic ulcers) most commonly occur on the feet, and affect up to 34% of patients with diabetes during their lifetime [1]. Diabetic wounds must be treated immediately to avoid infection that can lead to life threatening sepsis and/or amputation.

The data

Cynata’s Cymerus™ mesenchymal stem cells (MSCs) were used in an independent study conducted by the Cooperative Research Centre for Cell Therapy Manufacturing (CTM CRC) in a preclinical model of diabetic wounds.

CTM CRC evaluated cells from five different sources: Cymerus MSCs, bone marrow-derived MSCs supplied by a commercial manufacturer, and MSCs derived from dental pulp, bone chips and gingival fibroblasts (cells found in the gums).

The primary outcome measure was the extent of re-epithelialisation (skin restoration) of the wound surface after three days, which is representative of the speed of wound healing.

  • Dressings seeded with Cymerus MSCs resulted in significantly greater re-epithelialisation after three days (86 percent) than dressings seeded with commercially available bone marrow-derived MSCs (51 percent).
  • MSCs derived from dental pulp, gingival fibroblasts and bone chips resulted in re-epithelialisation of 68, 80 and 91 percent, respectively, after three days.

These results suggest that the most effective cell types for this application are Cymerus MSCs or MSCs derived from gingival fibroblasts or bone chips. However, the gingival fibroblast- and bone chip derived MSCs were produced in an academic laboratory under non-GMP conditions, and there are major challenges associated with producing clinical-grade cells from those sources at commercial scale. Conversely, Cynata’s Cymerus technology platform provides a readily available and effectively limitless source of consistent, clinical-grade MSCs.

[1] Diabetes Australia